Does gene therapy become pharmacotherapy?

نویسندگان

  • Ryuichi Morishita
  • Motokuni Aoki
  • Toshio Ogihara
چکیده

Recent progress in molecular and cellular biology has led to the development of numerous effective cardiovascular drugs. However, there are still a number of diseases for which no known effective therapy exists, such as peripheral arterial disease, ischaemic heart disease, restenosis after angioplasty, and vascular bypass graft occlusion. Currently, gene therapy is emerging as a potential strategy for the treatment of cardiovascular disease despite its limitations. The first human trial in gene therapy for cardiovascular disease was started at 1994 to treat peripheral vascular disease using vascular endothelial growth factor (VEGF). Then, many different potent angiogenic growth factors were tested in clinical trials to treat peripheral arterial disease and ischaemic heart disease. Improvement of clinical symptoms in peripheral arterial disease and ischaemic heart disease has been reported. This review focuses on the future potential of gene therapy for the treatment of cardiovascular disease. In the future, gene therapy might become a real pharmacotherapy to treat cardiovascular disease.

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Comparing the Effectiveness of Metacognitive Therapy (MCT), Pharmacotherapy (SSRIs) and EEG Biofeedback in Generalized Anxiety Disorders

Background and Objective: Generalized Anxiety Disorder (GAD) is one of the most common psychological disorders characterized by excessive and uncontrollable worry and it has ahigh comorbidity with other anxiety disorders and depression. The aim of this study was to compare the efficacy of metacognitive therapy (MCT), pharmacotherapy and neurofeedback treatment in treating Iranian patients with ...

متن کامل

The Efficacy of Matrix Model Treatment in the Reduction of Addiction Severity and Relapse Prevention among Amphetamine Abusers

Background and Objective: Amphetamine abuse has become a major problem in recent years. The aim of this study was to examine the efficacy of Matrix Model treatment in  amphetamine abusers. Materials and Methods: This study was a clinical trial with a pretest-posttest design. The study population included all known abusers of amphetamines in Zanjan, Iran.The sample consisted of 40 people referr...

متن کامل

Comparing the effectiveness of pharmacotherapy (paroxetine), modular cognitive-‎ behavioral therapy ‎‌‌and their combination in distress tolerance, ambiguity tolerance and meta-worry‎ in female university students with generalized anxiety disorder

Introduction In the last two decades, the interest in understanding the nature of generalized anxiety disorder (GAD) and the development of effective treatment methods for GAD has increased among psychologists. This study aimed to compare the effectiveness of pharmacotherapy, modular cognitive-‎behavioral therapy ‎‏‏and their combination in distress tolerance, ambiguity tolerance and meta-worr...

متن کامل

Efficacy of Pharmacotherapy and Cognitive Therapy, Alone and in Combination in Major Depressive Disorder

Introduction & Objective: Patients with Major depressive are difficult to treat, and the relative efficacy of medications and cognitive therapy in the treatment of depression is still a matter of deabath. The purpose of this study was to compare the efficacies of antidepressant medication, cognitive therapy and combination of cognitive therapy and antidepressant medication. Materials & Met...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

عنوان ژورنال:
  • Experimental physiology

دوره 90 3  شماره 

صفحات  -

تاریخ انتشار 2005